Оптимізація та масштабування методу синтезу похідних азаіндолу

• Date: 2025
• Main Authors: Kordubailo, Mykyta V., Tolmachev, Andrey A.
• Format: Article
• Language: English
• Published: National University of Pharmacy 2025
• Subjects: азаіндоли; реакція Соногашіри; синтез Ларока; карбонілювання
• Online Access: https://ophcj.nuph.edu.ua/article/view/323307
• Journal Title: Journal of Organic and Pharmaceutical Chemistry

In this study, an optimized method for the synthesis of azaindoles was developed and successfully scaled up to a 100 g batch. Improved yields were observed when using electron-deficient azaheterocycles and substrates bearing electron-withdrawing substituents. 6-Chloro-1H-pyrrolo[3,2-c]pyridine was s...