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Оптимізація та масштабування методу синтезу похідних азаіндолу

In this study, an optimized method for the synthesis of azaindoles was developed and successfully scaled up to a 100 g batch. Improved yields were observed when using electron-deficient azaheterocycles and substrates bearing electron-withdrawing substituents. 6-Chloro-1H-pyrrolo[3,2-c]pyridine was s...

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Bibliographic Details
Published in:Журнал органічної та фармацевтичної хімії
Date:2025
Volume:23
Issue:3
Pages:4-10
ISSN:2518-1548
Author Affiliations:
  • Mykyta V. Kordubailo — Institute of Organic Chemistry of the National Academy of Sciences of Ukraine; Enamine Ltd
  • Andrey A. Tolmachev — Taras Shevchenko National University of Kyiv — ORCID: 0009-0001-4351-2829
Main Authors: Kordubailo, Mykyta V., Tolmachev, Andrey A.
Format: Article
Language:English
Published: National University of Pharmacy 2025
Subjects:
азаіндоли
реакція Соногашіри
синтез Ларока
карбонілювання
Online Access:https://ophcj.nuph.edu.ua/article/view/323307
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Journal Title:Journal of Organic and Pharmaceutical Chemistry
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Journal of Organic and Pharmaceutical Chemistry

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